DMP1 Processing is Essential to Dentin and Jaw Formation

DMP1 is essential for osteocyte formation and function.

Dentin matrix protein 1 (DMP1).

Dentin matrix protein 1 (DMP1) expression in developing human teeth.

Dentin matrix protein 1 (DMP1) is an acidic phosphoprotein that plays an important role in mineralized tissue formation by initiation of nucleation and modulation of mineral phase morphology. The purpose of the present study was to examine the immunoexpression of DMP1 in tooth germs of 7 human fetuses at different gestational ages (14, 16, 19, 20, 21, 23 and 24 weeks) comparing with completed t...

Postoperative Monitoring Following Jaw Surgery Is Essential

Though there are no available statistics, about 5,000 cosmetic jaw operations seem to be performed yearly in South Korea [1]. The frequency of jaw surgery is increasing in South Korea and in the United States. Recently, serious complications, including mortality, have been reported in the mass media. An editorial of a Korean daily newspaper insisted that the Korean Medical Association and the a...

Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis.

Dentin matrix protein 1 (DMP1) is an acidic protein that plays critical roles in osteogenesis and dentinogenesis. Protein chemistry studies have demonstrated that DMP1 primarily exists as processed NH₂⁻ and COOH-terminal fragments in the extracellular matrix of bone and dentin. Our earlier work showed that the substitution of Asp²¹³ (a residue at a cleavage site) by Ala²¹³ blocks the processing...